Jun 2019 – Aug 2019 Translational Bioinformatics Intern
Early Stage Immuno-Oncology, Bristol-Myers Squibb
▪ Curated and analyzed clinical trial data of over 400 patients with advanced NSCLC enrolled in the FRACTION program which examined the efficacy of multiple IO treatment combinations.
▪ Interrogated the mutational and gene expression signatures, genes, pathways, and biomarkers associated with different outcomes in IO-Naïve and IO-Experienced patients using internal NGS data and the TCGA database.
▪ Developed and curated bioinformatics pipelines using R in AWS platform for parsing clinical data, pathogenic variant filtering, statistical tests for association analyses, and data visualization.
Mar 2016 – Present Graduate Research Assistant
Yale University & The Rockefeller University (Dr. Richard P. Lifton)
▪ Led a multi-national genomic study on the genetic mechanism of Vein of Galen malformation (VOGM), coordinating multiple research groups across 4 nations, resulting in 2 first-authored publications in Neuron and Trends in Molecular Medicine (cover story).
▪ Collaborated with clinical fellows on investigation of genetic mechanism of congenital hydrocephalus, resulting in a second-authored cover story in Neuron.
▪ Led the de novo analysis on the world’s largest cohort of congenital heart disease (CHD) with over 4,000 patients, resulting in a co-authored publication in Nature Genetics.
▪ Worked extensively with clinicians and statisticians worldwide on genomic studies of various congenital disorders and development of genomic tools, resulting in 6 co-authored publications.
▪ Built in-house bioinformatics pipelines for data processing and visualization, variant calling, and statistical association analyses of germline, somatic, mosaic, and structural variants.
Jun 2012 – May 2015 Undergraduate Research Assistant
Center for Human Genome Research (Dr. Qing Wang), HUST
▪ Mutation screen on > 1,000 CHD patients using High Resolution Melting Analysis.
▪ Conducted in vitro glutathione S-transferase (GST) pull down and Western blot to identify the interaction site between MOG1 and Nav1.5.
Key laboratory of Molecular Physics (Dr. Yunjun Yan), HUST
▪ Performed molecular cloning, targeted mutagenesis, vector transformation, enzyme assays and characterized the expression of 4 cellulases in bioengineering projects in E. coli and yeast.
▪ Worked with 18 undergraduate researchers as a leader of an experimental team of 4 members to design two synthetic biology projects winning Silver Medals in both the iGEM (International Genetically Engineered Machine Competition) Asian (2013) and Global (2014) Jamborees